Measuring fixed charge density of goat articular cartilage using indentation methods and biochemical analysis
نویسندگان
چکیده
منابع مشابه
Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography.
Small animal models of osteoarthritis are often used for evaluating the efficacy of pharmacologic treatments and cartilage repair strategies, but noninvasive techniques capable of monitoring matrix-level changes are limited by the joint size and the low radiopacity of soft tissues. Here we present a technique for the noninvasive imaging of cartilage at micrometer-level resolution based on detec...
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The negative charges on proteoglycans significantly affect the mechanical behaviors of articular cartilage. Mixture theories, such as the triphasic theory, can describe quantitatively how this charged nature contributes to the mechano-electrochemical behaviors of such tissue. However, the mathematical complexity of the theory has hindered its application to complicated loading profiles, e.g., i...
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Different methods have been used to cross-validate cartilage thickness measurements from magnetic resonance images (MRIs); however, a majority of these methods rely on interpolated data points, regional mean and/or maximal thickness, or surface mean thickness for data analysis. Furthermore, the accuracy of MRI cartilage thickness measurements from commercially available software packages has no...
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هدف از این مطالعه بررسی امکان استفاده از داروهای شناخته شده در درمان سایر بیماریها به عنوان داروهای ضد سرطان است. همچنین با استفاده از این داروها در ساختمان کمپلکس فلز می توان شاخص های دارویی بدست آمده را بررسی نمود. داروی ضد ویروس ایدز(hiv)به نام زیدوودین(azt)انتخاب و.کمپلکس.محلول.در.آب[pt(azt)2]cl2سنتزو به روشهای مختلف فیزیکی و شیمیایی شناسایی گردید. بر هم کنش مقایسه ای این دارو و کمپلکس پلا...
15 صفحه اولValidation of Articular Cartilage Tensile Moduli from Transversely Isotropic Biphasic Indentation Fem Analysis
Indentation testing has frequently been used as a method to obtain the material properties of articular cartilage in compression [1]. To account for the wellestablished anisotropic nature of cartilage [2] previous studies have modeled the cartilage as a transversely isotropic biphasic material using optimized FEM curvefitting techniques to obtain the material properties of the tissue in compres...
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ژورنال
عنوان ژورنال: Journal of Biomechanics
سال: 2008
ISSN: 0021-9290
DOI: 10.1016/j.jbiomech.2007.09.035